Department of Chemistry and Biochemistry
Organic/Inorganic/Materials Seminar Series

Professor Jonathan Kuo, Penn State
Hosted by ADSE

Comparing Metalloenzymatic Active Sites to Synthetic Model Complexes: Expanding Views on Supporting Ligands

Organic ligands alter the electronic structure and properties of the transition metals that they bind to. But what other functions can be programmed into metal/ligand complexes? In this talk, we will discuss how dynamic ligand features “unlock” key steps in (a) aerobic oxygenation and (b) electrophilic olefin activation. These dynamic features replicate dynamics present in enzymatic active sites. Recently, comparisons to enzymatic active sites have drawn us to host-guest-type ligand-metalate complexes – where the supporting ligand is designed to bind polyatomic metal anions [MO4]2– or [MCl4]2– via hydrogen bonding.