Knight Campus Faculty Tenure Seminar — Marian Hettiaratchi
Monday, October 31, 2022 11am to 12pm
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Phil and Penny Knight Campus for Accelerating Scientific Impact, Beetham Family Seminar Room
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Free Event
1505 Franklin Boulevard, Eugene, OR 97403-6231
"Modulating Protein Delivery for Tissue Repair using Engineered Affinity-based Biomaterials"
Recombinant protein delivery is a promising approach to stimulate tissue regeneration following traumatic injury or disease. Yet, limited strategies are available to adequately localize sufficient quantities of bioactive, therapeutic proteins within injury sites to stimulate healing. Biomaterials that leverage reversible affinity interactions between proteins and materials can enable precise, tunable control over protein localization and release in vivo. The Hettiaratchi lab aims to engineer affinity interactions between therapeutic proteins and biomaterials to create delivery vehicles that can exert precise control over protein bioactivity and delivery. This seminar will demonstrate how novel approaches in protein engineering, polymer chemistry, and directed evolution can be used to overcome the limitations of traditional biomaterial delivery vehicles and advance clinically-relevant strategies for tissue repair.
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